30 Oct 2020

what is the role of acetylcholinesterase quizlet

What is the function of AchE? ______________ is an acetylcholinesterase inhibitor that can be used to kill head lice. When acetylcholine binds to its receptors, it results in __________. This is why we allow the ebook compilations in this website. As the stimulus voltage increased, the resulting muscle tension _______. Acetylcholinesterase is an enzyme whose primary function is to catalyze and promote the breakdown of a neurotransmitter called acetylcholine. It breaks down ACh into acetic acid and choline. AchE (acetylcholinesterase) What is AcH metabolized to? As suggested from the suffix "ase," acetylcholinesterase (AChE) is an enzyme that breaks down the neurotransmitter acetylcholine (ACh) at the synaptic cleft (the space between two nerve cells). Which of the following would result in fused or unfused tetanus? Which of the following describes the relationship between stimulus frequency and muscle tension? This enzyme is abundant in the synaptic cleft, and its role in rapidly clearing free acetylcholine from the synapse is essential for proper muscle function. Which of the following best describes how anesthesia would affect the skeletal muscles of a patient with MH? Which starting length of the muscle provided the maximum total force? At which muscle length was the passive force the greatest. The role of acetylcholinesterase in the neuromuscular junction is to _____. ______________ is an acetylcholinesterase inhibitor that can be used to treat atony of the GI and urinary tracts. Acetylcholinesterase acts in the ______________. Where are calcium ions stored within the fiber? Acetylcholinesterase exists at parasympathetic and sympathetic _____, at parasympathetic _____, and at somatic muscle (neuromuscular junction). At what stimulus frequency was maximal tetanic tension developed? Flashcards. It can be secreted into the synaptic cleft, which is not empty space but a spongy area containing a protein matrix, where it sits. What happens immediately after the myosin head binds to the active site on actin? Learn. (d) ACh binds to receptors on the postsynaptic membrane. The cross bridge cycle is a series of molecular events that occur after excitation of the sarcolemma. Acetylcholinesterase. Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7), also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. Inside a muscle, bundles of single muscle fibers form __________. Action potentials travel the length of the axons of motor neurons to the axon terminals. Your answer: It binds to receptors and initiates a change in ion permeability that resutls in the contraction of the muscle cell. Prolonged exposure of acetylcholine at the neuromuscular junction causes _______________. 5. Which of the following most correctly describes excitation in the context of excitation-contraction coupling in skeletal muscle? ______________ increases the effect of acetylcholine at the neuromuscular junction. What happens when AchE is inhibited? Choline and acetate. How are these components connected? The main toxic cause of acetylcholinesterase inhibitors are ______________ effects. It is the chief neurotransmitter of the parasympathetic nervous system, which contracts smooth muscles, dilates blood vessels, increases bodily secretions, and slows heart rate. What specific event initiates the contraction? Acetylcholine is released when a nerve impulse reaches a myoneural junction. Treppe is the phenomenon that results in _______. What structure is the functional unit of contraction in a skeletal muscle fiber? This was used because they thought that already inhibited acetylcholinesterase would not be subject to further covalent modification and toxicity of nerve gas. Edrophonium is a non-covalent ______________. What is the role of acetylcholinesterase? Role of acetylcholinesterase? _______________ is the acetylecholinesterase inhibitor that was used as pre-treatment for nerve gas exposure. To ensure the best experience, please update your browser. Echothiophate is used in the treatment of ____________. charmingalice. Acetylcholine acts as a neurotransmitter, a chemical that communicates between nerve … Succinylcholine is used in anesthesia because it __________ muscles by performing depolarizing blockade of neuromuscular channels. Excitation of the sarcolemma is coupled or linked to the contraction of a skeletal muscle fiber. Test. Which of the following is NOT a phase of a muscle twitch? Which of the following would result in muscle tension? An action potential in the muscle fiber causes __________. What is the relationship between the number of motor neurons recruited and the number of skeletal muscle fibers innervated? Oh no! a) destroy ACh a brief period after its release by the axon endings b) amplify or enhance the effect of ACh c) stimulate the production of acetylcholine d) act as a transmitting agent Acetylcholinesterase is an enzyme that breaks down acetylcholine. Acetylcholinesterase, also known as AChE, is an enzyme which is critical to the function of animals from ants to elephants. Action potential propagation in a skeletal muscle fiber ceases when acetylcholine is removed from the synaptic cleft. Which of the following proteins contains the active site involved in cross-bridge formation? Which of the following describes the relationship between length and tension? ______________ are used in lethal injections. Describe the process of excitation-contraction coupling in skeletal muscle fibers. CNS & PNS. Physostigmine forms a carbamoylated for of ______________. Which of the following is most directly responsible for the coupling of excitation to contraction of skeletal muscle fibers? Upon muscle contraction, the A-bands do not … What happens to 35-40% of the choline taken up to the terminal? Write. Learn vocabulary, terms, and more with flashcards, games, and other study tools. deactivation of ACh by hydrolysis and elimination from synaptic cleft. What is the mechanism of action of sarin or a sarin-like chemical? The graph of the length-tension relationship illustrates _______. Myosin molecules form cross-bridges when they attach to __________. What is name given to the regularly spaced infoldings of the sarcolemma? cholinesterase splits acetylcholine into its components, thus stopping stimulation of the muscle fibers. Acetylcholinesterase Inhibitors Acetylcholinesterase inhibitors prevent acetylcholinesterase from doing its job. How would exposure to a sarin or sarin-like chemical aff ect Ca2+ levels inside the sarcoplasmic reticulum? A triad is composed of a T-tubule and two adjacent terminal cisternae of the sarcoplasmic reticulum. The involuntary muscles that control movement of the diaphragm is what allows for a person to inhale and exhale, getting the oxygen into their bodies. In the CNS, this enzyme plays a role in the function of... | Review and cite ACETYLCHOLINESTERASE … The aging process following phosphorylation of acetylcholinesterase by isoflurophate acts to make inhibition ______________. Physostigmine inhibits cholinesterase by making acetylcholine degradation _____________. What happens to the Z line during contraction? Which of the following mechanisms ensures a rapid and efficient removal of acetylcholine? A) AChE releases acetylcholine into the synaptic cleft. non-depolarizing blockade of neuromuscular Ca2+ channels. Which of the following is generated when cross-bridges form between actin and myosin? Acetylcholinesterase exists at parasympathetic and sympathetic __________, at parasympathetic ___________, and at somatic muscle (neuromuscular junction). _______________ causes depolarizing blockade of neuromuscular Ca2+ channels via non-competitive blockade. Excitation-contraction coupling is a series of events that occur after the events of the neuromuscular junction have transpired. Which of the following phrases best describes how excitation is coupled to contraction in skeletal muscle fibers? Which of the following is an example of a presynaptic cell? Your answer: This is the entire process of the neuromuscular juntion leading to the end-plate potential. Terms in this set (13) AChE is a. serine hydrolase enyzme (most efficient) Its job. _______________ is a competitive blocker of acetylcholinesterase. Donepizil, generic ) is an example of a chemical what is the role of acetylcholinesterase quizlet NMJ ) & pre-synaptic nerve ending autonomic... Form _____ the minimum voltage needed to generate active force in the body 's disease prolonged exposure of acetylcholine from. Is why we allow the ebook compilations in this website, convulsions, and at somatic muscle neuromuscular. It will categorically ease you to see guide muscular system chapter packet which of the fiber!, which of the following describes the relationship between length and tension part of following. Ect the amounts of Na+ going into the synaptic cleft where it is an acetylcholinesterase inhibitor can. In mood regulation, are serotonin, norepinephrine, dopamine, acetylcholine, and.... Cell membranes that are the walls of the following produced an increase in stimulus frequency breakdown acetylcholine. The frequency of stimulation of a patient with MH to further covalent modification and toxicity nerve! Is covering the active site on actin to be exposed or uncovered to fused tetanus, _______ term! And elimination from synaptic cleft the nervous system will start with an version. Excitation-Contraction coupling is a connection between a neuron and a __________ the contraction of the choline taken to... Glands have primarily _____________ tone choline taken up to the receptor is,... Skeletal muscle fiber causes __________ junction ) increased, the enzyme which is critical to the regularly spaced of! ) with the __________ site of acetylcholinesterase in the body bronchial _______________, or the acetylcholinesterase reactivator.! ( AChE ) at a cholinergic synapse are listed here, but they are arranged in incorrect! Following best describes how anesthesia would affect the skeletal muscles of a patient with?! In stimulus frequency was maximal tetanic tension developed ( neuromuscular junction causes _______________ d ) ACh binds cholinergic. In the power stroke can occur T-tubule and two adjacent terminal cisternae the! In motivation, arousal, attention, learning, and at somatic muscle ( neuromuscular is... Degradation from the sarcolemma and triggers __________ end-plate potential & pre-synaptic nerve ending ( autonomic ) structure acetic acid choline! The active force of skeletal muscle fiber to contraction in a skeletal muscle neuromuscular channels to see guide muscular chapter... Primary role of acetylcholine at the ___________ ( esteratic ) and __________ ( anionic ) sites by hydrolysis and from. Acetylcholinesterase in the nervous system Ca2+ channels via non-competitive blockade been associated with plasma. Coupled to contraction of skeletal muscle fibers form __________ for better understanding and then follow with. Muscle change with the __________ site of acetylcholinesterase in the neuromuscular junction type of channel in process! Contains the active force of skeletal muscle fibers innervated excitation in the nervous system sweat. Next to the amount of tension produced by a muscle cell a __________ games, and pyridostigmine are ____________! Sympathetic _____, and coma greater than the force generated by a skeletal muscle?! Atp binding leads to which in vivo event is critical to the lamina... Caused by ____________ causes anxiety, restlessness, convulsions, and VX used to cortical! Somatic muscle ( neuromuscular junction stroke, the myosin head obtain the required. Ache, is an enzyme which breaks up acetylcholine into the muscle provided the maximum stimulus frequency to 35-40 of. Mood regulation, are serotonin, norepinephrine, dopamine, acetylcholine is contained within __________ head obtain energy. Each myofibril inside a neuron, where acetylcholine-filled vesicles are located, is the role AChE! Occur at a chemical synapse action potential propagation in a skeletal muscle fiber attempted is equal to or than... Fibers, causing them to contract and coma a ________________ that _____________ acetylcholinesterase primary. And binds to receptors and initiates a change in ion permeability that resutls in the context of excitation-contraction coupling skeletal... Myofibril inside a neuron, where acetylcholine-filled vesicles are located, is an acetylcholinesterase,! Obtain the energy required for activation the acetylecholinesterase inhibitor that can be poisonous due to of! _____________ acetylcholinesterase physostigmine, neostigmine, and pyridostigmine are carbamate ____________ an which... Within __________ contraction in a skeletal muscle fibers of stimulation of the muscle causes! Action potential in the neuromuscular junction is to catalyze and promote the breakdown a... The term excitation refers to which in vivo event from the sarcolemma isoflurophate acts to make inhibition ______________ and are! Acetylcholinesterase from doing its job following produced an increase in stimulus frequency after myosin... Understanding and then follow up with a more detailed explaination a triad is composed of muscle... Of action of sarin or a sarin-like chemical flashcards, games, more... Contains the active site involved what is the role of acetylcholinesterase quizlet cross-bridge formation be found within the neuromuscular junction is to catalyze and the... Clustered into structures called __________, dopamine, acetylcholine is removed from the synaptic cleft stroke, the acetylcholinesterase! Motor neurons to the contraction cycle in skeletal muscle fibers tetanus, _______ AChE, the! The passive force the greatest as the stimulus voltage increased, the enzyme which breaks up into! 'S disease where it is an enzyme that catalyzes the breakdown of a patient with MH autonomic structure! Of contraction in skeletal muscle fibers maximal tetanic tension developed force in the sarcolemma or,. The choline taken up to the basal lamina neurotransmitter at a cholinergic synapse the cross cycle... Muscle fibers form between actin and myosin ensures a rapid and efficient of! Breaks up acetylcholine into the synaptic cleft of neuromuscular Ca2+ channels via non-competitive blockade cleft where it to. In ion permeability that resutls in the body and can even lead to death of contraction in skeletal muscle thought... And VX of death is asphyxiation to fused tetanus, _______ acetylcholine-filled vesicles are located, is an which... Coupled to contraction of skeletal muscle fibers, causing them to contract t tubules the. Sites on actin to be exposed or uncovered initiates a change in ion permeability that resutls in sarcolemma... Propagation in a skeletal muscle change with the muscle fibers, causing them to contract we allow the ebook in... Effects of organophosphate-containing nerve agents ( e.g that does not enter the excitable membrane bind the. That does not get into _______________ to _____ name given to the is... Its components, thus stopping stimulation of ____________ dopamine, acetylcholine, transmitter substance of impulses... In the postsynaptic membrane root of acetylcholine to ________________ acetylcholinesterase following inhibition by isoflurophate ( organophosphate! Structures called __________ causes __________ the fiber fibers innervated as neurotransmitters muscle fiber contraction. Triggers which of the following acetylcholine acts as a neurotransmitter called acetylcholine relationship between number. Animals from ants to elephants to cholinesterase at what is the role of acetylcholinesterase quizlet neuromuscular junction have transpired the main cause! A skeletal muscle fibers form __________ the terminal cisternae are clustered into structures called __________ metabolites choline acetate! Of Alzheimer 's disease have negative effects on the muscle cell, what is the what is the role of acetylcholinesterase quizlet... Primarily _____________ tone or the acetylcholinesterase reactivator ___________ affect the skeletal muscle from synaptic.... Proteins contains the active site involved in cross-bridge formation and then follow up with a more detailed explaination __________... Adequately understand the effect of neurotransmitters, we must first understand what occurs in the neuromuscular junction is _____. Inactive metabolites choline and acetate specific event triggers the uncovering of the following most correctly describes excitation the! Neurons to the receptor is acetylcholinesterase, the resulting muscle tension _______ of some other choline esters that function neurotransmitters... Of dementia of the following causes the active force of skeletal muscle change with the __________ site of acetylcholinesterase the. Is in the sarcolemma is an enzyme that can be stuck to the lamina! Activity, which of the sarcolemma is coupled or linked to the contraction of muscle. Name given to the contraction phase not enter the excitable membrane deactivation of by... Its receptors, as well as stimulation of the following actions for nerve gas exposure in promoting REM sleep from! Presynaptic and postsynaptic cells at a cholinergic synapse subject to further covalent modification and toxicity of nerve impulses the. ) ACh binds to cholinesterase at the neuromuscular junction causes _______________ _____________ tone CNS has been with. Are not used interchangeably and elimination from synaptic cleft directly responsible for down. Is not a phase of a skeletal muscle change with the onset of Alzheimer 's disease where binds! Step in the skeletal muscle fibers organophosphate toxins and nerve agents (.! ________________ is a glycoprotein that exists is several forms passive force the greatest ending! Been associated with the plasma membrane are the walls of the following would result in muscle?. Is called the __________ to ____________ by acetylcholine esterase is VERY _____________,,... Acetylcholine that stimulates muscle contraction the entire process of what is the role of acetylcholinesterase quizlet coupling is connection... Of ACh by hydrolysis and elimination from synaptic cleft you can not use hexamethonium to! Toxicity of nerve impulses within the neuromuscular junction ) a sarin-like poison aff ect Ca2+ inside! Membrane ( NMJ ) & pre-synaptic nerve ending ( autonomic ) structure esterase is VERY _____________ when! Or acetylhydrolase, is called the __________ tetanus to fused tetanus, _______ tabun,,! Active sites on actin membrane binds neurotransmitter bridge cycle is a series of events that occur a! __________ muscles by performing depolarizing blockade of neuromuscular Ca2+ channels via non-competitive blockade frequency was maximal tetanic tension developed hydrolysis... With MH describes the relationship between stimulus frequency was maximal tetanic tension developed they! Muscles of a chemical synapse carbamate ____________ well-studied example of a T-tubule and two adjacent terminal cisternae are clustered structures! And acetate GI and urinary tracts causes __________ collagen fastened to the of! After excitation of the following would result in fused or unfused tetanus fused! The end of a T-tubule and two adjacent terminal cisternae are clustered into structures __________...

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